In vivo genome and base editing of a human PCSK9 knock-in hypercholesterolemic mouse model

BACKGROUND: Plasma concentration of low-density lipoprotein (LDL) cholesterol is a well-established risk factor for cardiovascular disease. Inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9), which regulates cholesterol homeostasis, has recently emerged as an approach to reduce chol...

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Detalles Bibliográficos
Autores principales: Carreras, Alba, Pane, Luna Simona, Nitsch, Roberto, Madeyski-Bengtson, Katja, Porritt, Michelle, Akcakaya, Pinar, Taheri-Ghahfarokhi, Amir, Ericson, Elke, Bjursell, Mikael, Perez-Alcazar, Marta, Seeliger, Frank, Althage, Magnus, Knöll, Ralph, Hicks, Ryan, Mayr, Lorenz M., Perkins, Rosie, Lindén, Daniel, Borén, Jan, Bohlooly-Y, Mohammad, Maresca, Marcello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334452/
https://www.ncbi.nlm.nih.gov/pubmed/30646909
http://dx.doi.org/10.1186/s12915-018-0624-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334452/
https://www.ncbi.nlm.nih.gov/pubmed/30646909
http://dx.doi.org/10.1186/s12915-018-0624-2

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