The Medial Septum Is Insulin Resistant in the AD Presymptomatic Phase: Rescue by Nerve Growth Factor-Driven IRS(1) Activation

Basal forebrain cholinergic neurons (BFCN) are key modulators of learning and memory and are high energy-demanding neurons. Impaired neuronal metabolism and reduced insulin signaling, known as insulin resistance, has been reported in the early phase of Alzheimer’s disease (AD), which has been sugges...

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Detalles Bibliográficos
Autores principales: Sposato, Valentina, Canu, Nadia, Fico, Elena, Fusco, Salvatore, Bolasco, Giulia, Ciotti, Maria Teresa, Spinelli, Matteo, Mercanti, Delio, Grassi, Claudio, Triaca, Viviana, Calissano, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334735/
https://www.ncbi.nlm.nih.gov/pubmed/29736736
http://dx.doi.org/10.1007/s12035-018-1038-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334735/
https://www.ncbi.nlm.nih.gov/pubmed/29736736
http://dx.doi.org/10.1007/s12035-018-1038-4

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