Extracellular Alpha-Synuclein Oligomers Induce Parkin S-Nitrosylation: Relevance to Sporadic Parkinson’s Disease Etiopathology

α-Synuclein (ASN) and parkin, a multifunctional E3 ubiquitin ligase, are two proteins that are associated with the pathophysiology of Parkinson’s disease (PD). Excessive release of ASN, its oligomerization, aggregation, and deposition in the cytoplasm contribute to neuronal injury and cell death thr...

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Detalles Bibliográficos
Autores principales: Wilkaniec, Anna, Lenkiewicz, Anna M., Czapski, Grzegorz A., Jęśko, Henryk M., Hilgier, Wojciech, Brodzik, Robert, Gąssowska-Dobrowolska, Magdalena, Culmsee, Carsten, Adamczyk, Agata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334739/
https://www.ncbi.nlm.nih.gov/pubmed/29681024
http://dx.doi.org/10.1007/s12035-018-1082-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334739/
https://www.ncbi.nlm.nih.gov/pubmed/29681024
http://dx.doi.org/10.1007/s12035-018-1082-0

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