Preclinical toxicity and pharmacokinetics of a new orally bioavailable flubendazole formulation and the impact for clinical trials and risk/benefit to patients

BACKGROUND: Flubendazole, originally developed to treat infections with intestinal nematodes, has been shown to be efficacious in animal models of filarial infections. For treatment of filarial nematodes, systemic exposure is needed. For this purpose, an orally bioavailable amorphous solid dispersio...

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Detalles Bibliográficos
Autores principales: Lachau-Durand, Sophie, Lammens, Lieve, van der Leede, Bas-jan, Van Gompel, Jacky, Bailey, Graham, Engelen, Marc, Lampo, Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334931/
https://www.ncbi.nlm.nih.gov/pubmed/30650076
http://dx.doi.org/10.1371/journal.pntd.0007026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334931/
https://www.ncbi.nlm.nih.gov/pubmed/30650076
http://dx.doi.org/10.1371/journal.pntd.0007026

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