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Therapeutic Fc fusion protein misfolding: A three-phasic cultivation experimental design
Cell culture process optimization is a critical solution to most of the challenges faced by the pharmaceutical manufacturing. One of the major problems encountered in large-scale production of therapeutic proteins is misfolded protein production. The accumulation of misfolded therapeutic proteins is...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334962/ https://www.ncbi.nlm.nih.gov/pubmed/30650123 http://dx.doi.org/10.1371/journal.pone.0210712 |