Epistasis between Pax6(Sey) and genetic background reinforces the value of defined hybrid mouse models for therapeutic trials

The small eye (Sey) mouse is a model of PAX6-aniridia syndrome (aniridia). Aniridia, a congenital ocular disorder caused by heterozygous loss-of-function mutations in PAX6, needs new vision saving therapies. However, high phenotypic variability in Sey mice makes development of such therapies challen...

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Detalles Bibliográficos
Autores principales: Hickmott, Jack W., Gunawardane, Uvini, Jensen, Kimberly, Korecki, Andrea J., Simpson, Elizabeth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335240/
https://www.ncbi.nlm.nih.gov/pubmed/30258099
http://dx.doi.org/10.1038/s41434-018-0043-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335240/
https://www.ncbi.nlm.nih.gov/pubmed/30258099
http://dx.doi.org/10.1038/s41434-018-0043-6

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