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Epistasis between Pax6(Sey) and genetic background reinforces the value of defined hybrid mouse models for therapeutic trials
The small eye (Sey) mouse is a model of PAX6-aniridia syndrome (aniridia). Aniridia, a congenital ocular disorder caused by heterozygous loss-of-function mutations in PAX6, needs new vision saving therapies. However, high phenotypic variability in Sey mice makes development of such therapies challen...
Autores principales: | Hickmott, Jack W., Gunawardane, Uvini, Jensen, Kimberly, Korecki, Andrea J., Simpson, Elizabeth M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335240/ https://www.ncbi.nlm.nih.gov/pubmed/30258099 http://dx.doi.org/10.1038/s41434-018-0043-6 |
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