Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia

The neuronal microtubule-associated protein tau, MAPT, is central to the pathogenesis of many dementias. Autosomal-dominant mutations in MAPT cause inherited frontotemporal dementia (FTD), but the underlying pathogenic mechanisms are unclear. Using human stem cell models of FTD due to MAPT mutations...

Descripción completa

Detalles Bibliográficos
Autores principales: Paonessa, Francesco, Evans, Lewis D., Solanki, Ravi, Larrieu, Delphine, Wray, Selina, Hardy, John, Jackson, Stephen P., Livesey, Frederick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335264/
https://www.ncbi.nlm.nih.gov/pubmed/30650353
http://dx.doi.org/10.1016/j.celrep.2018.12.085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335264/
https://www.ncbi.nlm.nih.gov/pubmed/30650353
http://dx.doi.org/10.1016/j.celrep.2018.12.085

Ejemplares similares