A GMCSF-Neuroantigen Tolerogenic Vaccine Elicits Systemic Lymphocytosis of CD4(+) CD25(high) FOXP3(+) Regulatory T Cells in Myelin-Specific TCR Transgenic Mice Contingent Upon Low-Efficiency T Cell Antigen Receptor Recognition

Previous studies showed that single-chain fusion proteins comprised of GM-CSF and major encephalitogenic peptides of myelin, when injected subcutaneously in saline, were potent tolerogenic vaccines that suppressed experimental autoimmune encephalomyelitis (EAE) in rats and mice. These tolerogenic va...

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Detalles Bibliográficos
Autores principales: Moorman, Cody D., Curtis, Alan D., Bastian, Alexander G., Elliott, Sarah E., Mannie, Mark D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335336/
https://www.ncbi.nlm.nih.gov/pubmed/30687323
http://dx.doi.org/10.3389/fimmu.2018.03119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335336/
https://www.ncbi.nlm.nih.gov/pubmed/30687323
http://dx.doi.org/10.3389/fimmu.2018.03119

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