Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity

USP7 is a highly abundant deubiquitinating enzyme (DUB), involved in cellular processes including DNA damage response and apoptosis. USP7 has an unusual catalytic mechanism, where the low intrinsic activity of the catalytic domain (CD) increases when the C-terminal Ubl domains (Ubl45) fold onto the...

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Detalles Bibliográficos
Autores principales: Kim, Robbert Q., Geurink, Paul P., Mulder, Monique P. C., Fish, Alexander, Ekkebus, Reggy, El Oualid, Farid, van Dijk, Willem J., van Dalen, Duco, Ovaa, Huib, van Ingen, Hugo, Sixma, Titia K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335408/
https://www.ncbi.nlm.nih.gov/pubmed/30651545
http://dx.doi.org/10.1038/s41467-018-08231-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335408/
https://www.ncbi.nlm.nih.gov/pubmed/30651545
http://dx.doi.org/10.1038/s41467-018-08231-5

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