A Contraction Stress Model of Hypertrophic Cardiomyopathy due to Sarcomere Mutations

Thick-filament sarcomere mutations are a common cause of hypertrophic cardiomyopathy (HCM), a disorder of heart muscle thickening associated with sudden cardiac death and heart failure, with unclear mechanisms. We engineered four isogenic induced pluripotent stem cell (iPSC) models of β-myosin heavy...

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Detalles Bibliográficos
Autores principales: Cohn, Rachel, Thakar, Ketan, Lowe, Andre, Ladha, Feria A., Pettinato, Anthony M., Romano, Robert, Meredith, Emily, Chen, Yu-Sheng, Atamanuk, Katherine, Huey, Bryan D., Hinson, J. Travis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335568/
https://www.ncbi.nlm.nih.gov/pubmed/30554920
http://dx.doi.org/10.1016/j.stemcr.2018.11.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335568/
https://www.ncbi.nlm.nih.gov/pubmed/30554920
http://dx.doi.org/10.1016/j.stemcr.2018.11.015

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