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Elevated H3K27me3 levels sensitize osteosarcoma to cisplatin

BACKGROUND: In osteosarcoma (OS), chemotherapy resistance has become one of the greatest issues leading to high mortality among patients. However, the mechanisms of drug resistance remain elusive, limiting therapeutic efficacy. Here, we set out to explore the relationship between dynamic histone cha...

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Detalles Bibliográficos
Autores principales: He, Chao, Sun, Jian, Liu, Chao, Jiang, Yuhang, Hao, Yongqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335728/
https://www.ncbi.nlm.nih.gov/pubmed/30651137
http://dx.doi.org/10.1186/s13148-018-0605-x