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Elevated H3K27me3 levels sensitize osteosarcoma to cisplatin
BACKGROUND: In osteosarcoma (OS), chemotherapy resistance has become one of the greatest issues leading to high mortality among patients. However, the mechanisms of drug resistance remain elusive, limiting therapeutic efficacy. Here, we set out to explore the relationship between dynamic histone cha...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335728/ https://www.ncbi.nlm.nih.gov/pubmed/30651137 http://dx.doi.org/10.1186/s13148-018-0605-x |