Cathepsin C promotes microglia M1 polarization and aggravates neuroinflammation via activation of Ca(2+)-dependent PKC/p38MAPK/NF-κB pathway

BACKGROUND: Microglia-derived lysosomal cathepsins are important inflammatory mediators to trigger signaling pathways in inflammation-related cascades. Our previous study showed that the expression of cathepsin C (CatC) in the brain is induced predominantly in activated microglia in neuroinflammatio...

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Detalles Bibliográficos
Autores principales: Liu, Qing, Zhang, Yanli, Liu, Shuang, Liu, Yanna, Yang, Xiaohan, Liu, Gang, Shimizu, Takahiro, Ikenaka, Kazuhiro, Fan, Kai, Ma, Jianmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335804/
https://www.ncbi.nlm.nih.gov/pubmed/30651105
http://dx.doi.org/10.1186/s12974-019-1398-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335804/
https://www.ncbi.nlm.nih.gov/pubmed/30651105
http://dx.doi.org/10.1186/s12974-019-1398-3

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