Photoactivatable platinum anticancer complex can generate tryptophan radicals

l-Tryptophan (Trp), melatonin (MLT) and the Trp-peptide pentagastrin quenched the formation of azidyl radicals generated on irradiation of the anticancer complex trans,trans,trans-[Pt(pyridine)(2)(N(3))(2)(OH)(2)] with visible light, giving rise to C3-centred indole radicals which were characterized...

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Detalles Bibliográficos
Autores principales: Vallotto, Claudio, Shaili, Evyenia, Shi, Huayun, Butler, Jennifer S., Wedge, Christopher J., Newton, Mark E., Sadler, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336088/
https://www.ncbi.nlm.nih.gov/pubmed/30468213
http://dx.doi.org/10.1039/c8cc06496b
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author Vallotto, Claudio
Shaili, Evyenia
Shi, Huayun
Butler, Jennifer S.
Wedge, Christopher J.
Newton, Mark E.
Sadler, Peter J.
author_facet Vallotto, Claudio
Shaili, Evyenia
Shi, Huayun
Butler, Jennifer S.
Wedge, Christopher J.
Newton, Mark E.
Sadler, Peter J.
author_sort Vallotto, Claudio
collection PubMed
description l-Tryptophan (Trp), melatonin (MLT) and the Trp-peptide pentagastrin quenched the formation of azidyl radicals generated on irradiation of the anticancer complex trans,trans,trans-[Pt(pyridine)(2)(N(3))(2)(OH)(2)] with visible light, giving rise to C3-centred indole radicals which were characterized for Trp and MLT using an EPR spin-trap; indole, together with azidyl and hydroxyl radicals, have potential roles in a multitargeting mechanism of action against resistant cancers.
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spelling pubmed-63360882019-02-11 Photoactivatable platinum anticancer complex can generate tryptophan radicals Vallotto, Claudio Shaili, Evyenia Shi, Huayun Butler, Jennifer S. Wedge, Christopher J. Newton, Mark E. Sadler, Peter J. Chem Commun (Camb) Chemistry l-Tryptophan (Trp), melatonin (MLT) and the Trp-peptide pentagastrin quenched the formation of azidyl radicals generated on irradiation of the anticancer complex trans,trans,trans-[Pt(pyridine)(2)(N(3))(2)(OH)(2)] with visible light, giving rise to C3-centred indole radicals which were characterized for Trp and MLT using an EPR spin-trap; indole, together with azidyl and hydroxyl radicals, have potential roles in a multitargeting mechanism of action against resistant cancers. Royal Society of Chemistry 2018-12-21 2018-11-23 /pmc/articles/PMC6336088/ /pubmed/30468213 http://dx.doi.org/10.1039/c8cc06496b Text en This journal is © The Royal Society of Chemistry 2018 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)
spellingShingle Chemistry
Vallotto, Claudio
Shaili, Evyenia
Shi, Huayun
Butler, Jennifer S.
Wedge, Christopher J.
Newton, Mark E.
Sadler, Peter J.
Photoactivatable platinum anticancer complex can generate tryptophan radicals
title Photoactivatable platinum anticancer complex can generate tryptophan radicals
title_full Photoactivatable platinum anticancer complex can generate tryptophan radicals
title_fullStr Photoactivatable platinum anticancer complex can generate tryptophan radicals
title_full_unstemmed Photoactivatable platinum anticancer complex can generate tryptophan radicals
title_short Photoactivatable platinum anticancer complex can generate tryptophan radicals
title_sort photoactivatable platinum anticancer complex can generate tryptophan radicals
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336088/
https://www.ncbi.nlm.nih.gov/pubmed/30468213
http://dx.doi.org/10.1039/c8cc06496b
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