Mutation, drift and selection in single-driver hematologic malignancy: Example of secondary myelodysplastic syndrome following treatment of inherited neutropenia

Cancer development is driven by series of events involving mutations, which may become fixed in a tumor via genetic drift and selection. This process usually includes a limited number of driver (advantageous) mutations and a greater number of passenger (neutral or mildly deleterious) mutations. We f...

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Detalles Bibliográficos
Autores principales: Wojdyla, Tomasz, Mehta, Hrishikesh, Glaubach, Taly, Bertolusso, Roberto, Iwanaszko, Marta, Braun, Rosemary, Corey, Seth J., Kimmel, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336352/
https://www.ncbi.nlm.nih.gov/pubmed/30615612
http://dx.doi.org/10.1371/journal.pcbi.1006664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336352/
https://www.ncbi.nlm.nih.gov/pubmed/30615612
http://dx.doi.org/10.1371/journal.pcbi.1006664

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