Transition from metal-DTH resistance to susceptibility is facilitated by NLRP3 inflammasome signaling induced Th17 reactivity: Implications for orthopedic implants

Metal hypersensitivity has been recognized as an adverse biologic reaction that can compromise total joint arthroplasty (TJA) performance. However, the etiology of metal hypersensitivity responses in TJAs remains unclear. Metal implant debris is known to act as a danger signal that drives NLRP3 infl...

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Detalles Bibliográficos
Autores principales: Samelko, Lauryn, Caicedo, Marco S., Jacobs, Joshua, Hallab, Nadim James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336398/
https://www.ncbi.nlm.nih.gov/pubmed/30653583
http://dx.doi.org/10.1371/journal.pone.0210336

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336398/
https://www.ncbi.nlm.nih.gov/pubmed/30653583
http://dx.doi.org/10.1371/journal.pone.0210336

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