Distinct Roles of Extracellular Domains in the Epstein-Barr Virus-Encoded BILF1 Receptor for Signaling and Major Histocompatibility Complex Class I Downregulation

The Epstein-Barr virus (EBV) BILF1 gene encodes a constitutively active G protein-coupled receptor (GPCR) that downregulates major histocompatibility complex (MHC) class I and induces signaling-dependent tumorigenesis. Different BILF1 homologs display highly conserved extracellular loops (ECLs) incl...

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Detalles Bibliográficos
Autores principales: Fares, Suzan, Spiess, Katja, Olesen, Emma T. B., Zuo, Jianmin, Jackson, Sarah, Kledal, Thomas N., Wills, Mark R., Rosenkilde, Mette M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336419/
https://www.ncbi.nlm.nih.gov/pubmed/30647152
http://dx.doi.org/10.1128/mBio.01707-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336419/
https://www.ncbi.nlm.nih.gov/pubmed/30647152
http://dx.doi.org/10.1128/mBio.01707-18

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