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Distinct Roles of Extracellular Domains in the Epstein-Barr Virus-Encoded BILF1 Receptor for Signaling and Major Histocompatibility Complex Class I Downregulation

The Epstein-Barr virus (EBV) BILF1 gene encodes a constitutively active G protein-coupled receptor (GPCR) that downregulates major histocompatibility complex (MHC) class I and induces signaling-dependent tumorigenesis. Different BILF1 homologs display highly conserved extracellular loops (ECLs) incl...

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Detalles Bibliográficos
Autores principales:	Fares, Suzan, Spiess, Katja, Olesen, Emma T. B., Zuo, Jianmin, Jackson, Sarah, Kledal, Thomas N., Wills, Mark R., Rosenkilde, Mette M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336419/ https://www.ncbi.nlm.nih.gov/pubmed/30647152 http://dx.doi.org/10.1128/mBio.01707-18

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