In silico Assessment of Pharmacotherapy for Human Atrial Patho-Electrophysiology Associated With hERG-Linked Short QT Syndrome

Short QT syndrome variant 1 (SQT1) arises due to gain-of-function mutations to the human Ether-à-go-go-Related Gene (hERG), which encodes the α subunit of channels carrying rapid delayed rectifier potassium current, I(Kr). In addition to QT interval shortening and ventricular arrhythmias, SQT1 is as...

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Detalles Bibliográficos
Autores principales: Whittaker, Dominic G., Hancox, Jules C., Zhang, Henggui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336736/
https://www.ncbi.nlm.nih.gov/pubmed/30687112
http://dx.doi.org/10.3389/fphys.2018.01888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336736/
https://www.ncbi.nlm.nih.gov/pubmed/30687112
http://dx.doi.org/10.3389/fphys.2018.01888

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