High frequencies of circulating memory T cells specific for calreticulin exon 9 mutations in healthy individuals

Mutations in exon 9 of the calreticulin gene (CALR) frequently occur in patients with chronic myeloproliferative neoplasms (MPN). Patients exhibit spontaneous cellular immune responses to epitopes derived from the mutant CALR C-terminus, and CALR-mutant-specific T cells recognize autologous CALR-mut...

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Detalles Bibliográficos
Autores principales: Holmström, Morten O., Ahmad, Shamaila M., Klausen, Uffe, Bendtsen, Simone K., Martinenaite, Evelina, Riley, Caroline H., Svane, Inge M., Kjær, Lasse, Skov, Vibe, Ellervik, Christina, Pallisgaard, Niels, Hasselbalch, Hans C., Andersen, Mads H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336769/
https://www.ncbi.nlm.nih.gov/pubmed/30655510
http://dx.doi.org/10.1038/s41408-018-0166-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336769/
https://www.ncbi.nlm.nih.gov/pubmed/30655510
http://dx.doi.org/10.1038/s41408-018-0166-4

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