Domain insertion permissibility-guided engineering of allostery in ion channels

Allostery is a fundamental principle of protein regulation that remains hard to engineer, particularly in membrane proteins such as ion channels. Here we use human Inward Rectifier K(+) Channel Kir2.1 to map site-specific permissibility to the insertion of domains with different biophysical properti...

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Detalles Bibliográficos
Autores principales: Coyote-Maestas, Willow, He, Yungui, Myers, Chad L., Schmidt, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336875/
https://www.ncbi.nlm.nih.gov/pubmed/30655517
http://dx.doi.org/10.1038/s41467-018-08171-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336875/
https://www.ncbi.nlm.nih.gov/pubmed/30655517
http://dx.doi.org/10.1038/s41467-018-08171-0

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