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Domain insertion permissibility-guided engineering of allostery in ion channels
Allostery is a fundamental principle of protein regulation that remains hard to engineer, particularly in membrane proteins such as ion channels. Here we use human Inward Rectifier K(+) Channel Kir2.1 to map site-specific permissibility to the insertion of domains with different biophysical properti...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336875/ https://www.ncbi.nlm.nih.gov/pubmed/30655517 http://dx.doi.org/10.1038/s41467-018-08171-0 |