Use of trifluoroacetaldehyde N-tfsylhydrazone as a trifluorodiazoethane surrogate and its synthetic applications

Trifluorodiazoethane (CF(3)CHN(2)), a highly reactive fluoroalkylating reagent, offers a useful means to introduce trifluoromethyl groups into organic molecules. At present, CF(3)CHN(2) can only be generated by oxidation of trifluoroethylamine hydrochloride under acidic conditions; due to its toxic...

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Detalles Bibliográficos
Autores principales: Zhang, Xinyu, Liu, Zhaohong, Yang, Xiangyu, Dong, Yuanqing, Virelli, Matteo, Zanoni, Giuseppe, Anderson, Edward A., Bi, Xihe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336877/
https://www.ncbi.nlm.nih.gov/pubmed/30655536
http://dx.doi.org/10.1038/s41467-018-08253-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336877/
https://www.ncbi.nlm.nih.gov/pubmed/30655536
http://dx.doi.org/10.1038/s41467-018-08253-z

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