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Use of trifluoroacetaldehyde N-tfsylhydrazone as a trifluorodiazoethane surrogate and its synthetic applications
Trifluorodiazoethane (CF(3)CHN(2)), a highly reactive fluoroalkylating reagent, offers a useful means to introduce trifluoromethyl groups into organic molecules. At present, CF(3)CHN(2) can only be generated by oxidation of trifluoroethylamine hydrochloride under acidic conditions; due to its toxic...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336877/ https://www.ncbi.nlm.nih.gov/pubmed/30655536 http://dx.doi.org/10.1038/s41467-018-08253-z |