Autophagy–lysosome pathway alterations and alpha-synuclein up-regulation in the subtype of neuronal ceroid lipofuscinosis, CLN5 disease

Neuronal ceroid lipofuscinoses (NCLs) are a group of inherited neurodegenerative lysosomal storage disorders. CLN5 deficiency causes a subtype of NCL, referred to as CLN5 disease. CLN5 is a soluble lysosomal protein with an unclear function in the cell. Increased levels of the autophagy marker prote...

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Detalles Bibliográficos
Autores principales: Adams, Jessie, Feuerborn, Melissa, Molina, Joshua A., Wilden, Alexa R., Adhikari, Babita, Budden, Theodore, Lee, Stella Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336884/
https://www.ncbi.nlm.nih.gov/pubmed/30655561
http://dx.doi.org/10.1038/s41598-018-36379-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336884/
https://www.ncbi.nlm.nih.gov/pubmed/30655561
http://dx.doi.org/10.1038/s41598-018-36379-z

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