A Flexible Synthesis of (68)Ga-Labeled Carbonic Anhydrase IX (CAIX)-Targeted Molecules via CBT/1,2-Aminothiol Click Reaction

We herein describe a flexible synthesis of a small library of (68)Ga-labeled CAIX-targeted molecules via an orthogonal 2-cyanobenzothiazole (CBT)/1,2-aminothiol click reaction. Three novel CBT-functionalized chelators (1–3) were successfully synthesized and labeled with the positron emitter gallium-...

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Detalles Bibliográficos
Autores principales: Chen, Kuo-Ting, Nguyen, Kevin, Ieritano, Christian, Gao, Feng, Seimbille, Yann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337199/
https://www.ncbi.nlm.nih.gov/pubmed/30577607
http://dx.doi.org/10.3390/molecules24010023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337199/
https://www.ncbi.nlm.nih.gov/pubmed/30577607
http://dx.doi.org/10.3390/molecules24010023

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