Cargando…

A Flexible Synthesis of (68)Ga-Labeled Carbonic Anhydrase IX (CAIX)-Targeted Molecules via CBT/1,2-Aminothiol Click Reaction

We herein describe a flexible synthesis of a small library of (68)Ga-labeled CAIX-targeted molecules via an orthogonal 2-cyanobenzothiazole (CBT)/1,2-aminothiol click reaction. Three novel CBT-functionalized chelators (1–3) were successfully synthesized and labeled with the positron emitter gallium-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Kuo-Ting, Nguyen, Kevin, Ieritano, Christian, Gao, Feng, Seimbille, Yann
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337199/ https://www.ncbi.nlm.nih.gov/pubmed/30577607 http://dx.doi.org/10.3390/molecules24010023

Ejemplares similares

Early‐Stage Incorporation Strategy for Regioselective Labeling of Peptides using the 2‐Cyanobenzothiazole/ 1,2‐Aminothiol Bioorthogonal Click Reaction
por: Chen, Kuo‐Ting, et al.
Publicado: (2018)

Early‐Stage Incorporation Strategy for Regioselective Labeling of Peptides using the 2‐Cyanobenzothiazole/1,2‐Aminothiol Bioorthogonal Click Reaction
por: Chen, Kuo‐Ting, et al.
Publicado: (2018)

Front Cover: Early‐Stage Incorporation Strategy for Regioselective Labeling of Peptides using the 2‐Cyanobenzothiazole/1,2‐Aminothiol Bioorthogonal Click Reaction (ChemistryOpen 3/2018)
por: Chen, Kuo‐Ting, et al.
Publicado: (2018)

Carbonic Anhydrase IX (CAIX), Cancer, and Radiation Responsiveness
por: Ward, Carol, et al.
Publicado: (2018)

New Developments in Carbonic Anhydrase IX-Targeted Fluorescence and Nuclear Imaging Agents
por: Chen, Kuo-Ting, et al.
Publicado: (2022)

Development of a (68)Ga‐labelled PET tracer for carbonic anhydrase IX‐overexpressed tumors using the artificial sweetener saccharin
por: Shin, Un chul, et al.
Publicado: (2020)

Hypoxia-regulated carbonic anhydrase IX (CAIX) protein is an independent prognostic indicator in triple negative breast cancer
por: Ong, Chong Hui Clara, et al.
Publicado: (2022)

The relationship between carbonic anhydrase IX (CAIX) and patient survival in breast cancer: systematic review and meta-analysis
por: Shamis, Suad A. K., et al.
Publicado: (2023)

Exploring the Role of Hypoxia-Inducible Carbonic Anhydrase IX (CAIX) in Circulating Tumor Cells (CTCs) of Breast Cancer
por: Twomey, Julianne D., et al.
Publicado: (2023)

Binding of the Phage Display Derived Peptide CaIX-P1 on Human Colorectal Carcinoma Cells Correlates with the Expression of Carbonic Anhydrase IX
por: Askoxylakis, Vasileios, et al.
Publicado: (2012)

Genetic Encoding of Cyanopyridylalanine for In‐Cell Protein Macrocyclization by the Nitrile–Aminothiol Click Reaction
por: Abdelkader, Elwy H., et al.
Publicado: (2022)

Expression of transmembrane carbonic anhydrases, CAIX and CAXII, in human development
por: Liao, Shu-Yuan, et al.
Publicado: (2009)

Preclinical validations of [(18)F]FPyPEGCBT-c(RGDfK): a (18)F-labelled RGD peptide prepared by ligation of 2-cyanobenzothiazole and 1,2-aminothiol to image angiogenesis
por: Colin, Didier J., et al.
Publicado: (2016)

Imaging of carbonic anhydrase IX with an (111)In-labeled dual-motif inhibitor
por: Yang, Xing, et al.
Publicado: (2015)

Investigation of the Prognostic Role of Carbonic Anhydrase 9 (CAIX) of the Cellular mRNA/Protein Level or Soluble CAIX Protein in Patients with Oral Squamous Cell Carcinoma
por: Eckert, Alexander W., et al.
Publicado: (2019)

Design, synthesis and evaluation of (18)F-labeled cationic carbonic anhydrase IX inhibitors for PET imaging
por: Zhang, Zhengxing, et al.
Publicado: (2017)

Copper-Free ‘Click’ Chemistry-Based Synthesis and Characterization of Carbonic Anhydrase-IX Anchored Albumin-Paclitaxel Nanoparticles for Targeting Tumor Hypoxia
por: Tatiparti, Katyayani, et al.
Publicado: (2018)

Design, Synthesis and Biological Evaluation of New Carbohydrate-Based Coumarin Derivatives as Selective Carbonic Anhydrase IX Inhibitors via “Click” Reaction
por: Chu, Naying, et al.
Publicado: (2022)

Carbonic anhydrase IX in oligodendroglial brain tumors
por: Järvelä, Sally, et al.
Publicado: (2008)

Targeting Carbonic Anhydrase IX Activity and Expression
por: Mahon, Brian P., et al.
Publicado: (2015)

Carbonic Anhydrase IX—Mouse versus Human
por: Takacova, Martina, et al.
Publicado: (2019)

Carbonic anhydrase IX and acid transport in cancer
por: Becker, Holger M.
Publicado: (2019)

Expression and prognostic value of carbonic anhydrase IX (CA-IX) in bladder urothelial carcinoma
por: Xiang, An-Ping, et al.
Publicado: (2022)

Cold Kit Labeling: The Future of (68)Ga Radiopharmaceuticals?
por: Lepareur, Nicolas
Publicado: (2022)

Past, Present, and Future: Development of Theranostic Agents Targeting Carbonic Anhydrase IX
por: Lau, Joseph, et al.
Publicado: (2017)

Biophysical Characterization of Cancer-Related Carbonic Anhydrase IX
por: Koruza, Katarina, et al.
Publicado: (2020)

Carbonic Anhydrases II, IX, and XII in Reflux Esophagitis
por: Nortunen, Minna, et al.
Publicado: (2021)

Primary Duodenal Adenocarcinoma Expressing Carbonic Anhydrase IX
por: Kubo, Kimitoshi, et al.
Publicado: (2022)

The (68)Ge/(68)Ga generator has high potential, but when can we use (68)Ga-labelled tracers in clinical routine?
por: Breeman, Wouter A. P., et al.
Publicado: (2007)

Antiretroviral activity of aminothiols, WR2721 and WR1065
por: Poirier, Miriam C, et al.
Publicado: (2006)

Soluble form of carbonic anhydrase IX (CA IX) in the serum and urine of renal carcinoma patients
por: Závada, J, et al.
Publicado: (2003)

Optimization of Automated Radiosynthesis of Gallium-68-Labeled PSMA11 with Two [(68)Ge]Ge/[(68)Ga]Ga Generators: Fractional Elution or Prepurification?
por: Durieux, Flore, et al.
Publicado: (2023)

Targeting carbonic anhydrase IX and XII isoforms with small molecule inhibitors and monoclonal antibodies
por: Kciuk, Mateusz, et al.
Publicado: (2022)

In vitro and in vivo comparative study of a novel (68)Ga-labeled PSMA-targeted inhibitor and (68)Ga-PSMA-11
por: Chen, Huanyu, et al.
Publicado: (2021)

Click chemistry approaches for developing carbonic anhydrase inhibitors and their applications
por: Angeli, Andrea, et al.
Publicado: (2023)

The effect of purification of Ga-68-labeled exendin on in vivo distribution
por: Brom, Maarten, et al.
Publicado: (2016)

(68)Ga‐Labelled Tropane Analogues for the Visualization of the Dopaminergic System
por: Häseli, Sascha, et al.
Publicado: (2020)

(68)Ga-labelled desferrioxamine-B for bacterial infection imaging
por: Petrik, Milos, et al.
Publicado: (2020)

Recent Developments in Targeting Carbonic Anhydrase IX for Cancer Therapeutics
por: McDonald, Paul C., et al.
Publicado: (2012)

Circulating Carbonic Anhydrase IX and Antiangiogenic Therapy in Breast Cancer
por: Brown-Glaberman, Ursa, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_1iknutes10u2gkn8p60i2ap9b4