Optimization of Sequence, Display, and Mode of Operation of IgG-Binding Peptide Ligands to Develop Robust, High-Capacity Affinity Adsorbents That Afford High IgG Product Quality

This work presents the use of peptide ligand HWRGWV and its cognate sequences to develop affinity adsorbents that compete with Protein A in terms of binding capacity and quality of the eluted product. First, the peptide ligand was conjugated to crosslinked agarose resins (WorkBeads) at different den...

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Detalles Bibliográficos
Autores principales: Islam, Tuhidul, Naik, Amith D., Hashimoto, Yasuhiro, Menegatti, Stefano, Carbonell, Ruben G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337475/
https://www.ncbi.nlm.nih.gov/pubmed/30621158
http://dx.doi.org/10.3390/ijms20010161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337475/
https://www.ncbi.nlm.nih.gov/pubmed/30621158
http://dx.doi.org/10.3390/ijms20010161

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