Cargando…

The Synergistic Effects of APOE Genotype and Obesity on Alzheimer’s Disease Risk

The APOE gene has three common alleles—E2, E3, and E4, with APOE4 being the strongest genetic risk factor for developing Alzheimer’s Disease (AD). Obesity is a global epidemic and contributes to multiple metabolic problems. Obesity is also a risk factor for cognitive decline. Here, we review the eff...

Descripción completa

Detalles Bibliográficos
Autores principales: Jones, Nahdia S., Rebeck, G. William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337558/
https://www.ncbi.nlm.nih.gov/pubmed/30586872
http://dx.doi.org/10.3390/ijms20010063
_version_ 1783388282810269696
author Jones, Nahdia S.
Rebeck, G. William
author_facet Jones, Nahdia S.
Rebeck, G. William
author_sort Jones, Nahdia S.
collection PubMed
description The APOE gene has three common alleles—E2, E3, and E4, with APOE4 being the strongest genetic risk factor for developing Alzheimer’s Disease (AD). Obesity is a global epidemic and contributes to multiple metabolic problems. Obesity is also a risk factor for cognitive decline. Here, we review the effects of APOE4 and obesity on cognition and AD development, independently and together. We describe studies that have associated APOE4 with cognitive deficits and AD, as well as studies that have associated obesity to cognitive deficits and AD. We then describe studies that have examined the effects of obesity and APOE genotypes together, with a focus on APOE4 and high fat diets. Both human studies and rodent models have contributed to understanding the effects of obesity on the different APOE genotypes, and we outline possible underlying mechanisms associated with these effects. Data across approaches support a model in which APOE4 and obesity combine for greater detrimental effects on metabolism and cognition, in ways that are influenced by both age and sex.
format Online
Article
Text
id pubmed-6337558
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-63375582019-01-22 The Synergistic Effects of APOE Genotype and Obesity on Alzheimer’s Disease Risk Jones, Nahdia S. Rebeck, G. William Int J Mol Sci Review The APOE gene has three common alleles—E2, E3, and E4, with APOE4 being the strongest genetic risk factor for developing Alzheimer’s Disease (AD). Obesity is a global epidemic and contributes to multiple metabolic problems. Obesity is also a risk factor for cognitive decline. Here, we review the effects of APOE4 and obesity on cognition and AD development, independently and together. We describe studies that have associated APOE4 with cognitive deficits and AD, as well as studies that have associated obesity to cognitive deficits and AD. We then describe studies that have examined the effects of obesity and APOE genotypes together, with a focus on APOE4 and high fat diets. Both human studies and rodent models have contributed to understanding the effects of obesity on the different APOE genotypes, and we outline possible underlying mechanisms associated with these effects. Data across approaches support a model in which APOE4 and obesity combine for greater detrimental effects on metabolism and cognition, in ways that are influenced by both age and sex. MDPI 2018-12-24 /pmc/articles/PMC6337558/ /pubmed/30586872 http://dx.doi.org/10.3390/ijms20010063 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jones, Nahdia S.
Rebeck, G. William
The Synergistic Effects of APOE Genotype and Obesity on Alzheimer’s Disease Risk
title The Synergistic Effects of APOE Genotype and Obesity on Alzheimer’s Disease Risk
title_full The Synergistic Effects of APOE Genotype and Obesity on Alzheimer’s Disease Risk
title_fullStr The Synergistic Effects of APOE Genotype and Obesity on Alzheimer’s Disease Risk
title_full_unstemmed The Synergistic Effects of APOE Genotype and Obesity on Alzheimer’s Disease Risk
title_short The Synergistic Effects of APOE Genotype and Obesity on Alzheimer’s Disease Risk
title_sort synergistic effects of apoe genotype and obesity on alzheimer’s disease risk
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337558/
https://www.ncbi.nlm.nih.gov/pubmed/30586872
http://dx.doi.org/10.3390/ijms20010063
work_keys_str_mv AT jonesnahdias thesynergisticeffectsofapoegenotypeandobesityonalzheimersdiseaserisk
AT rebeckgwilliam thesynergisticeffectsofapoegenotypeandobesityonalzheimersdiseaserisk
AT jonesnahdias synergisticeffectsofapoegenotypeandobesityonalzheimersdiseaserisk
AT rebeckgwilliam synergisticeffectsofapoegenotypeandobesityonalzheimersdiseaserisk