In Vivo Glycan Engineering via the Mannosidase I Inhibitor (Kifunensine) Improves Efficacy of Rituximab Manufactured in Nicotiana benthamiana Plants

N-glycosylation has been shown to affect the pharmacokinetic properties of several classes of biologics, including monoclonal antibodies, blood factors, and lysosomal enzymes. In the last two decades, N-glycan engineering has been employed to achieve a N-glycosylation profile that is either more con...

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Detalles Bibliográficos
Autores principales: Kommineni, Vally, Markert, Matthew, Ren, Zhongjie, Palle, Sreenath, Carrillo, Berenice, Deng, Jasmine, Tejeda, Armando, Nandi, Somen, McDonald, Karen A., Marcel, Sylvain, Holtz, Barry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337617/
https://www.ncbi.nlm.nih.gov/pubmed/30621113
http://dx.doi.org/10.3390/ijms20010194

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337617/
https://www.ncbi.nlm.nih.gov/pubmed/30621113
http://dx.doi.org/10.3390/ijms20010194

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