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In Vivo Glycan Engineering via the Mannosidase I Inhibitor (Kifunensine) Improves Efficacy of Rituximab Manufactured in Nicotiana benthamiana Plants

N-glycosylation has been shown to affect the pharmacokinetic properties of several classes of biologics, including monoclonal antibodies, blood factors, and lysosomal enzymes. In the last two decades, N-glycan engineering has been employed to achieve a N-glycosylation profile that is either more con...

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Detalles Bibliográficos
Autores principales:	Kommineni, Vally, Markert, Matthew, Ren, Zhongjie, Palle, Sreenath, Carrillo, Berenice, Deng, Jasmine, Tejeda, Armando, Nandi, Somen, McDonald, Karen A., Marcel, Sylvain, Holtz, Barry
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337617/ https://www.ncbi.nlm.nih.gov/pubmed/30621113 http://dx.doi.org/10.3390/ijms20010194

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