Identification of Novel Potential Inhibitors of Pteridine Reductase 1 in Trypanosoma brucei via Computational Structure-Based Approaches and in Vitro Inhibition Assays

Pteridine reductase 1 (PTR1) is a trypanosomatid multifunctional enzyme that provides a mechanism for escape of dihydrofolate reductase (DHFR) inhibition. This is because PTR1 can reduce pterins and folates. Trypanosomes require folates and pterins for survival and are unable to synthesize them de n...

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Detalles Bibliográficos
Autores principales: Kimuda, Magambo Phillip, Laming, Dustin, Hoppe, Heinrich C., Tastan Bishop, Özlem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337619/
https://www.ncbi.nlm.nih.gov/pubmed/30609681
http://dx.doi.org/10.3390/molecules24010142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337619/
https://www.ncbi.nlm.nih.gov/pubmed/30609681
http://dx.doi.org/10.3390/molecules24010142

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