MHY440, a Novel Topoisomerase Ι Inhibitor, Induces Cell Cycle Arrest and Apoptosis via a ROS-Dependent DNA Damage Signaling Pathway in AGS Human Gastric Cancer Cells

We investigated the antitumor activity and action mechanism of MHY440 in AGS human gastric cancer cells. MHY440 inhibited topoisomerase (Topo) Ι activity and was associated with a DNA damage response signaling pathway. It exhibited a stronger anti-proliferative effect on AGS cells relative to Hs27 h...

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Detalles Bibliográficos
Autores principales: Jang, Jung Yoon, Kang, Yong Jung, Sung, Bokyung, Kim, Min Jeong, Park, Chaeun, Kang, Dongwan, Moon, Hyung Ryong, Chung, Hae Young, Kim, Nam Deuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337620/
https://www.ncbi.nlm.nih.gov/pubmed/30597845
http://dx.doi.org/10.3390/molecules24010096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337620/
https://www.ncbi.nlm.nih.gov/pubmed/30597845
http://dx.doi.org/10.3390/molecules24010096

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