Cmah-dystrophin deficient mdx mice display an accelerated cardiac phenotype that is improved following peptide-PMO exon skipping treatment

Duchenne muscular dystrophy (DMD) is caused by loss of dystrophin protein, leading to progressive muscle weakness and premature death due to respiratory and/or cardiac complications. Cardiac involvement is characterized by progressive dilated cardiomyopathy, decreased fractional shortening and metab...

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Detalles Bibliográficos
Autores principales: Betts, Corinne A, McClorey, Graham, Healicon, Richard, Hammond, Suzan M, Manzano, Raquel, Muses, Sofia, Ball, Vicky, Godfrey, Caroline, Merritt, Thomas M, van Westering, Tirsa, O’Donovan, Liz, Wells, Kim E, Gait, Michael J, Wells, Dominic J, Tyler, Damian, Wood, Matthew J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337703/
https://www.ncbi.nlm.nih.gov/pubmed/30281092
http://dx.doi.org/10.1093/hmg/ddy346

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337703/
https://www.ncbi.nlm.nih.gov/pubmed/30281092
http://dx.doi.org/10.1093/hmg/ddy346

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