KIF18A's neck linker permits navigation of microtubule-bound obstacles within the mitotic spindle

KIF18A (kinesin-8) is required for mammalian mitotic chromosome alignment. KIF18A confines chromosome movement to the mitotic spindle equator by accumulating at the plus-ends of kinetochore microtubule bundles (K-fibers), where it functions to suppress K-fiber dynamics. It is not understood how the...

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Detalles Bibliográficos
Autores principales: Malaby, Heidi LH, Lessard, Dominique V, Berger, Christopher L, Stumpff, Jason
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337737/
https://www.ncbi.nlm.nih.gov/pubmed/30655363
http://dx.doi.org/10.26508/lsa.201800169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337737/
https://www.ncbi.nlm.nih.gov/pubmed/30655363
http://dx.doi.org/10.26508/lsa.201800169

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