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KIF18A's neck linker permits navigation of microtubule-bound obstacles within the mitotic spindle

KIF18A (kinesin-8) is required for mammalian mitotic chromosome alignment. KIF18A confines chromosome movement to the mitotic spindle equator by accumulating at the plus-ends of kinetochore microtubule bundles (K-fibers), where it functions to suppress K-fiber dynamics. It is not understood how the...

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Detalles Bibliográficos
Autores principales:	Malaby, Heidi LH, Lessard, Dominique V, Berger, Christopher L, Stumpff, Jason
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337737/ https://www.ncbi.nlm.nih.gov/pubmed/30655363 http://dx.doi.org/10.26508/lsa.201800169

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