Structural Determinants of the Prion Protein N-Terminus and Its Adducts with Copper Ions

The N-terminus of the prion protein is a large intrinsically disordered region encompassing approximately 125 amino acids. In this paper, we review its structural and functional properties, with a particular emphasis on its binding to copper ions. The latter is exploited by the region’s conformation...

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Detalles Bibliográficos
Autores principales: Sánchez-López, Carolina, Rossetti, Giulia, Quintanar, Liliana, Carloni, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337743/
https://www.ncbi.nlm.nih.gov/pubmed/30577569
http://dx.doi.org/10.3390/ijms20010018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337743/
https://www.ncbi.nlm.nih.gov/pubmed/30577569
http://dx.doi.org/10.3390/ijms20010018

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