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Structural Determinants of the Prion Protein N-Terminus and Its Adducts with Copper Ions
The N-terminus of the prion protein is a large intrinsically disordered region encompassing approximately 125 amino acids. In this paper, we review its structural and functional properties, with a particular emphasis on its binding to copper ions. The latter is exploited by the region’s conformation...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337743/ https://www.ncbi.nlm.nih.gov/pubmed/30577569 http://dx.doi.org/10.3390/ijms20010018 |