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Histone deacetylase inhibitors exert anti-tumor effects on human adherent and stem-like glioma cells
BACKGROUND: The diagnosis of glioblastoma (GBM), a most aggressive primary brain tumor with a median survival of 14.6 months, carries a dismal prognosis. GBMs are characterized by numerous genetic and epigenetic alterations, affecting patient survival and treatment response. Epigenetic mechanisms ar...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337817/ https://www.ncbi.nlm.nih.gov/pubmed/30654849 http://dx.doi.org/10.1186/s13148-018-0598-5 |