Different SUMO paralogues determine the fate of wild-type and mutant CFTRs: biogenesis versus degradation

A pathway for cystic fibrosis transmembrane conductance regulator (CFTR) degradation is initiated by Hsp27, which cooperates with Ubc9 and binds to the common F508del mutant to modify it with SUMO-2/3. These SUMO paralogues form polychains, which are recognized by the ubiquitin ligase, RNF4, for pro...

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Detalles Bibliográficos
Autores principales: Gong, Xiaoyan, Liao, Yong, Ahner, Annette, Larsen, Mads Breum, Wang, Xiaohui, Bertrand, Carol A., Frizzell, Raymond A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337916/
https://www.ncbi.nlm.nih.gov/pubmed/30403549
http://dx.doi.org/10.1091/mbc.E18-04-0252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337916/
https://www.ncbi.nlm.nih.gov/pubmed/30403549
http://dx.doi.org/10.1091/mbc.E18-04-0252

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