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Methodologies for Improving HDR Efficiency

Clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 (Cas9) is a precise genome manipulating technology that can be programmed to induce double-strand break (DSB) in the genome wherever needed. After nuclease cleavage, DSBs can be repaired by non-homologous end joi...

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Detalles Bibliográficos
Autores principales: Liu, Mingjie, Rehman, Saad, Tang, Xidian, Gu, Kui, Fan, Qinlei, Chen, Dekun, Ma, Wentao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338032/
https://www.ncbi.nlm.nih.gov/pubmed/30687381
http://dx.doi.org/10.3389/fgene.2018.00691