Cargando…

IRE1α Activation in Bone Marrow-Derived Dendritic Cells Modulates Innate Recognition of Melanoma Cells and Favors CD8(+) T Cell Priming

The IRE1α/XBP1s signaling pathway is an arm of the unfolded protein response (UPR) that safeguards the fidelity of the cellular proteome during endoplasmic reticulum (ER) stress, and that has also emerged as a key regulator of dendritic cell (DC) homeostasis. However, in the context of DC activation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Medel, Bernardita, Costoya, Cristobal, Fernandez, Dominique, Pereda, Cristian, Lladser, Alvaro, Sauma, Daniela, Pacheco, Rodrigo, Iwawaki, Takao, Salazar-Onfray, Flavio, Osorio, Fabiola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338037/ https://www.ncbi.nlm.nih.gov/pubmed/30687308 http://dx.doi.org/10.3389/fimmu.2018.03050

Ejemplares similares

The Unfolded Protein Response Sensor IRE1 Regulates Activation of In Vitro Differentiated Type 1 Conventional DCs with Viral Stimuli
por: Medel, Bernardita, et al.
Publicado: (2023)

Understanding the Role of the Unfolded Protein Response Sensor IRE1 in the Biology of Antigen Presenting Cells
por: Flores-Santibáñez, Felipe, et al.
Publicado: (2019)

Nuanced role for dendritic cell intrinsic IRE1 RNase in the regulation of antitumor adaptive immunity
por: Flores-Santibañez, Felipe, et al.
Publicado: (2023)

Caveolin-1 Expression Increases upon Maturation in Dendritic Cells and Promotes Their Migration to Lymph Nodes Thereby Favoring the Induction of CD8(+) T Cell Responses
por: Oyarce, Cesar, et al.
Publicado: (2017)

Role of Dendritic Cells in the Induction of Lymphocyte Tolerance
por: Osorio, Fabiola, et al.
Publicado: (2015)

Tumour cell lysate-loaded dendritic cell vaccine induces biochemical and memory immune response in castration-resistant prostate cancer patients
por: Reyes, D, et al.
Publicado: (2013)

Identification of a consensus element recognized and cleaved by IRE1α
por: Oikawa, Daisuke, et al.
Publicado: (2010)

CD73 Ectonucleotidase Restrains CD8+ T Cell Metabolic Fitness and Anti-tumoral Activity
por: Briceño, Pedro, et al.
Publicado: (2021)

IRE1–XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells
por: Tsuchiya, Yuichi, et al.
Publicado: (2018)

Direct Association of Unfolded Proteins with Mammalian ER Stress Sensor, IRE1β
por: Oikawa, Daisuke, et al.
Publicado: (2012)

Correction: IRE1–XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells
por: Tsuchiya, Yuichi, et al.
Publicado: (2019)

The IRE1/XBP1 signaling axis promotes skeletal muscle regeneration through a cell non-autonomous mechanism
por: Roy, Anirban, et al.
Publicado: (2021)

Preclinical evaluation of chimeric antigen receptor T cells targeting the carcinoembryonic antigen as a potential immunotherapy for gallbladder cancer
por: Lopez, Ernesto, et al.
Publicado: (2023)

IRE1α Disruption Causes Histological Abnormality of Exocrine Tissues, Increase of Blood Glucose Level, and Decrease of Serum Immunoglobulin Level
por: Iwawaki, Takao, et al.
Publicado: (2010)

Role of IRE1α in podocyte proteostasis and mitochondrial health
por: Navarro-Betancourt, José R., et al.
Publicado: (2020)

Proteomic Identification of Heat Shock-Induced Danger Signals in a Melanoma Cell Lysate Used in Dendritic Cell-Based Cancer Immunotherapy
por: González, Fermín E., et al.
Publicado: (2018)

Endoplasmic Reticulum Stress Sensor IRE1α Enhances IL-23 Expression by Human Dendritic Cells
por: Márquez, Saioa, et al.
Publicado: (2017)

IRE1α Promotes Zika Virus Infection via XBP1
por: Kolpikova, Elena P., et al.
Publicado: (2020)

Dead Tumor Cells Expressing Infectious Salmon Anemia Virus Fusogenic Protein Favor Antigen Cross-Priming In Vitro
por: Morales, Jonathan, et al.
Publicado: (2017)

Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha
por: Govindarajan, Srinath, et al.
Publicado: (2018)

IRE1α activation protects mice against acetaminophen-induced hepatotoxicity
por: Hur, Kyu Yeon, et al.
Publicado: (2012)

Hypoxic Melanoma Cells Deliver microRNAs to Dendritic Cells and Cytotoxic T Lymphocytes through Connexin-43 Channels
por: Tittarelli, Andrés, et al.
Publicado: (2020)

Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition
por: Inclan-Rico, Juan M., et al.
Publicado: (2020)

Deletion of the Unfolded Protein Response Transducer IRE1α Is Detrimental to Aging Photoreceptors and to ER Stress-Mediated Retinal Degeneration
por: Massoudi, Dawiyat, et al.
Publicado: (2023)

Vaccination-induced skin-resident memory CD8(+) T cells mediate strong protection against cutaneous melanoma
por: Gálvez-Cancino, Felipe, et al.
Publicado: (2018)

Unconventional Activation of IRE1 Enhances TH17 Responses and Promotes Neutrophilic Airway Inflammation
por: Wu, Dandan, et al.
Publicado: (2023)

IRE1α regulates macrophage polarization, PD-L1 expression, and tumor survival
por: Batista, Alyssa, et al.
Publicado: (2020)

ERα promotes murine hematopoietic regeneration through the Ire1α-mediated unfolded protein response
por: Chapple, Richard H, et al.
Publicado: (2018)

A heat-shocked melanoma cell lysate vaccine enhances tumor infiltration by prototypic effector T cells inhibiting tumor growth
por: Gleisner, María Alejandra, et al.
Publicado: (2020)

Intercepting IRE1 kinase‐FMRP signaling prevents atherosclerosis progression
por: Yildirim, Zehra, et al.
Publicado: (2022)

MITOL prevents ER stress‐induced apoptosis by IRE1α ubiquitylation at ER–mitochondria contact sites
por: Takeda, Keisuke, et al.
Publicado: (2019)

ERdj5 in Innate Immune Cells Is a Crucial Factor for the Mucosal Adjuvanticity of Cholera Toxin
por: Kim, Mee-Sun, et al.
Publicado: (2019)

Purinergic Signaling as a Regulator of Th17 Cell Plasticity
por: Fernández, Dominique, et al.
Publicado: (2016)

Human cDC1s display constitutive activation of the UPR sensor IRE1
por: García‐González, Paulina, et al.
Publicado: (2022)

Dendritic Cells Loaded with Heat Shock-Conditioned Ovarian Epithelial Carcinoma Cell Lysates Elicit T Cell-Dependent Antitumor Immune Responses In Vitro
por: Flores, Iván, et al.
Publicado: (2019)

Haptoglobin Induces a Specific Proteomic Profile and a Mature-Associated Phenotype on Primary Human Monocyte-Derived Dendritic Cells
por: Torres, Alfredo, et al.
Publicado: (2022)

Activation of Host IRE1α-Dependent Signaling Axis Contributes the Intracellular Parasitism of Brucella melitensis
por: Pandey, Aseem, et al.
Publicado: (2018)

Network Topologies and Dynamics Leading to Endotoxin Tolerance and Priming in Innate Immune Cells
por: Fu, Yan, et al.
Publicado: (2012)

Viral priming of cell intrinsic innate antiviral signaling by the unfolded protein response
por: Carletti, Tea, et al.
Publicado: (2019)

Targeting IRE1 endoribonuclease activity alleviates cardiovascular lesions in a murine model of Kawasaki disease vasculitis
por: Marek-Iannucci, Stefanie, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_f4qd1ap9205rra2vakoetgv69i