Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism

Pathways underlying metabolic reprogramming in cancer remain incompletely understood. We identify the transmembrane serine protease TMPRSS11B as a gene that promotes transformation of immortalized human bronchial epithelial cells (HBECs). TMPRSS11B is upregulated in human lung squamous cell carcinom...

Descripción completa

Detalles Bibliográficos
Autores principales: Updegraff, Barrett L., Zhou, Xiaorong, Guo, Yabin, Padanad, Mahesh S., Chen, Pei-Hsuan, Yang, Chendong, Sudderth, Jessica, Rodriguez-Tirado, Carla, Girard, Luc, Minna, John D., Mishra, Prashant, DeBerardinis, Ralph J., O’Donnell, Kathryn A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338450/
https://www.ncbi.nlm.nih.gov/pubmed/30463017
http://dx.doi.org/10.1016/j.celrep.2018.10.100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338450/
https://www.ncbi.nlm.nih.gov/pubmed/30463017
http://dx.doi.org/10.1016/j.celrep.2018.10.100

Ejemplares similares