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Cellular cartography of the organ of Corti based on optical tissue clearing and machine learning

The highly organized spatial arrangement of sensory hair cells in the organ of Corti is essential for inner ear function. Here, we report a new analytical pipeline, based on optical clearing of tissue, for the construction of a single-cell resolution map of the organ of Corti. A sorbitol-based optic...

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Detalles Bibliográficos
Autores principales: Urata, Shinji, Iida, Tadatsune, Yamamoto, Masamichi, Mizushima, Yu, Fujimoto, Chisato, Matsumoto, Yu, Yamasoba, Tatsuya, Okabe, Shigeo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338463/
https://www.ncbi.nlm.nih.gov/pubmed/30657453
http://dx.doi.org/10.7554/eLife.40946