Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity

Metformin, the first-line drug to treat type 2 diabetes (T2D), inhibits mitochondrial glycerolphosphate dehydrogenase in the liver to suppress gluconeogenesis. However, the direct target and the underlying mechanisms by which metformin increases glucose uptake in peripheral tissues remain uncharacte...

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Detalles Bibliográficos
Autores principales: Polianskyte-Prause, Zydrune, Tolvanen, Tuomas A., Lindfors, Sonja, Dumont, Vincent, Van, Mervi, Wang, Hong, Dash, Surjya N., Berg, Mika, Naams, Jette-Britt, Hautala, Laura C., Nisen, Harry, Mirtti, Tuomas, Groop, Per-Henrik, Wähälä, Kristiina, Tienari, Jukka, Lehtonen, Sanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338644/
https://www.ncbi.nlm.nih.gov/pubmed/30321069
http://dx.doi.org/10.1096/fj.201800529RR

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338644/
https://www.ncbi.nlm.nih.gov/pubmed/30321069
http://dx.doi.org/10.1096/fj.201800529RR

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