MEP50/PRMT5-mediated methylation activates GLI1 in Hedgehog signalling through inhibition of ubiquitination by the ITCH/NUMB complex

Transcription factor GLI1 is an effecter of Hedgehog (HH) signalling and activated in a broad spectrum of cancers. However, the role of the HH-GLI1 pathway in cancer and the activation mechanism of GLI1 in HH signalling after dissociation from its inhibitor, SUFU, are not fully understood. Here, we...

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Detalles Bibliográficos
Autores principales: Abe, Yoshinori, Suzuki, Yosuke, Kawamura, Kenji, Tanaka, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338668/
https://www.ncbi.nlm.nih.gov/pubmed/30675521
http://dx.doi.org/10.1038/s42003-018-0275-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338668/
https://www.ncbi.nlm.nih.gov/pubmed/30675521
http://dx.doi.org/10.1038/s42003-018-0275-4

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