Tadalafil treatment in mice for preeclampsia with fetal growth restriction has neuro-benefic effects in offspring through modulating prenatal hypoxic conditions

We have demonstrated that tadalafil facilitates fetal growth in mice with L-NG-nitroarginine methyl ester (L-NAME)-induced preeclampsia (PE) with fetal growth restriction (FGR). Tadalafil is a selective phosphodiesterase 5 inhibitor that dilates the maternal blood sinuses in the placenta, thereby fa...

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Detalles Bibliográficos
Autores principales: Tachibana, Ryota, Umekawa, Takashi, Yoshikawa, Kento, Owa, Takao, Magawa, Shoichi, Furuhashi, Fumi, Tsuji, Makoto, Maki, Shintaro, Shimada, Kyoko, Kaneda, Michiko K., Nii, Masafumi, Tanaka, Hiroaki, Tanaka, Kayo, Kamimoto, Yuki, Kondo, Eiji, Kato, Ineko, Ikemura, Kenji, Okuda, Masahiro, Ma, Ning, Miyoshi, Takekazu, Hosoda, Hiroshi, Endoh, Masayuki, Kimura, Tadashi, Ikeda, Tomoaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338749/
https://www.ncbi.nlm.nih.gov/pubmed/30659198
http://dx.doi.org/10.1038/s41598-018-36084-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338749/
https://www.ncbi.nlm.nih.gov/pubmed/30659198
http://dx.doi.org/10.1038/s41598-018-36084-x

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