Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming

Hepatocellular carcinomas (HCC) exhibit distinct promoter hypermethylation patterns, but the epigenetic regulation and function of transcriptional enhancers remain unclear. Here, our affinity- and bisulfite-based whole-genome sequencing analyses reveal global enhancer hypomethylation in human HCCs....

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Detalles Bibliográficos
Autores principales: Xiong, Lei, Wu, Feng, Wu, Qiong, Xu, Liangliang, Cheung, Otto K., Kang, Wei, Mok, Myth T., Szeto, Lemuel L. M., Lun, Cheuk-Yin, Lung, Raymond W., Zhang, Jinglin, Yu, Ken H., Lee, Sau-Dan, Huang, Guangcun, Wang, Chiou-Miin, Liu, Joseph, Yu, Zhuo, Yu, Dae-Yeul, Chou, Jian-Liang, Huang, Wan-Hong, Feng, Bo, Cheung, Yue-Sun, Lai, Paul B., Tan, Patrick, Wong, Nathalie, Chan, Michael W., Huang, Tim H., Yip, Kevin Y., Cheng, Alfred S., To, Ka-Fai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338783/
https://www.ncbi.nlm.nih.gov/pubmed/30659195
http://dx.doi.org/10.1038/s41467-018-08245-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338783/
https://www.ncbi.nlm.nih.gov/pubmed/30659195
http://dx.doi.org/10.1038/s41467-018-08245-z

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