RAGE is a Critical Mediator of Pulmonary Oxidative Stress, Alveolar Macrophage Activation and Emphysema in Response to Cigarette Smoke

The receptor for advanced glycation end products (RAGE), a cell membrane receptor, recognizes ligands produced by cigarette smoke (CS) and has been implicated in the pathogenesis of COPD. We demonstrate that deletion or pharmacologic inhibition of RAGE prevents development of CS-induced emphysema. T...

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Detalles Bibliográficos
Autores principales: Sanders, Karl A., Delker, Don A., Huecksteadt, Tom, Beck, Emily, Wuren, Tanna, Chen, Yuntian, Zhang, Yuxia, Hazel, Mark W., Hoidal, John R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338799/
https://www.ncbi.nlm.nih.gov/pubmed/30659203
http://dx.doi.org/10.1038/s41598-018-36163-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338799/
https://www.ncbi.nlm.nih.gov/pubmed/30659203
http://dx.doi.org/10.1038/s41598-018-36163-z

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